Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
نویسندگان
چکیده
منابع مشابه
Endovascular therapy after intravenous t-PA versus t-PA alone for stroke.
BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onse...
متن کاملStent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.
BACKGROUND Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome. ...
متن کاملACP Journal Club. Adding endovascular therapy to t-PA did not improve 90-day survival or functional independence after stroke.
Intervention: Administration of t-PA, maximum dose 90 mg, given as a 10% bolus and then as an infusion of 0.9 mg/kg over 40 to 60 minutes, followed by angiography and, if protocol criteria were met, endovascular therapy chosen by the site neurointerventionalist (endovascular group) (n = 434), or intraarterial t-PA given alone over 1 hour (n = 222). Randomization was done ≤ 40 minutes after star...
متن کاملMyocardial infarction following t-PA for acute stroke.
BACKGROUND AND PURPOSE Complications of intravenous (IV) thrombolysis with tissue plasminogen activator (t-PA) for acute stroke are commonly related to hemorrhage, anaphylaxis, or arterial re-occlusion. Embolic complications of t-PA are beginning to be recognized with increased use of t-PA for acute ischemic stroke. We hypothesize that disruption of intra-cardiac thrombus may result in myocardi...
متن کاملتأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) بر عوامل فیبرینولیتیک (t-PA، PAI-1 و کمپلکس t-PA/PAI-1) مردان جوان غیرفعال
هدف از پژوهش حاضر، بررسی تأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) بر عوامل فیبرینولیتیک (t-PA، PAI-1 و کمپلکس t-PA/PAI-1) مردان جوان غیرفعال بود. به این منظور، 18 مرد جوان غیرفعال به‌صورت داوطلبانه در این پژوهش شرکت کردند و به‌طور تصادفی به دو گروه تجربی (9n=، سن:41/1±33/24 سال، قد:91/4±22/176 سانتی‌متر، وزن:59/6±27/72 کیلوگرم) و کنترل (9n=، سن:01/2±27/23 سال، قد:88/6±22/180 سانتی‌متر، وزن...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2013
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1214300